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ÖZ Antibodies against hepatitis B virus (HBV) core antigen (antiHBc) are assumed to be the best serologically reliable markers of HBV infection. However, chronic HBV infection can be seen with an atypical serological profile, such as anti-HBc negativity with the presence of hepatitis B surface antigen (HBsAg). Anti-HBc negativity during HBV infection has been observed in a few different circumstances, such as infections with HBV variants, in infants born to hepatitis B envelope antigen positive carrier mothers and immunocompromised patients. In this case, we described a 21-yearold anti-HBc-negative male patient with chronic HBV infection.

A Case of Chronic Hepatitis B Virus Infection in an Anti-HBc-negative Patient: An Atypical Serological Profile