Relationship Between Human Papilloma Virus and Bladder Cancer

Human papilloma virus (HPV) is a DNA virus with more than 170 types. HPV is the most common sexually transmitted infection and 10% of the world’s cancer burden is thought to be HPV infection-related. It is known that precancerous lesions caused by some subgroups of this virus transformed into invasive carcinoma, and its place in etiology of cervix, vulva, oropharynx, anus and penile cancer is also well-known. Cases have been published where condyloma are seen not only in anogenital region, but also in urethra, bladder and ureter. However, their role in bladder cancer pathogenesis is questionable. Recent studies showed that HPV and bladder cancer are associated. Condyloma was identified to be in the development of squamous cell carcinoma of the bladder. In this review, the relationship between HPV-urothelial cancer and squamous cell carcinoma of the bladder is examined with references to the literature