Karaciğer hastalıklarında pıhtılaşma-tromboz mekanizmasına neler oluyor?

Children with liver disease present complex and varied acquired coagulation abnormalities. Liver is the place where clotting factors are produced as well as inhibitors of coagulation and fibrinolytic system components. Although 75-85% of patients with liver disease show abnormal laboratory values, only 10-15% will have clinical bleeding symptoms, as liver has a large factor reserve capacity.This paper will review acute and chronic liver disease and the hemostatic alterations. Treatment of the coagulopaty of liver disease is usually replacement of lacking factor and supportive care. Liver transplantation, which is very common recently, and its affects on hematological balance will also summarized. (Turk Arch Ped 2013; 48: 94-101