Osteoporosis in Thalassemia Major

last two decades the survival of the patients has improved considerably and osteoporosis has become a serious burden. Genetic and acquired factors play role in bone demineralization and osteoporosis is the most common involvement in the skeletal system. It is seen in %40-50 of Thalassemia major patients, even in well-treated ones. Therefore regular screening and preventive interventions are important in these patients. In addition to blood transfusions and iron chelation therapy; hormonal replacement therapy, calcium and vitamin D supplementation; antiresorptive drugs like bisphosphonates are used to inhibit osteoclast function.In this review, an overview of osteoporos is and its treatment modalities in patients with Thalassemia major are presented. (Turkish Journal of Osteoporosis 2012;18: 89-91)