Effect of Medium pH and Light on Quinidine Production in Cinchona calisaya Wedd. Endophytic Fungi | Zendy

Indriana Rahmawati | Zendy; Gayuh Rahayu | Zendy; Diah Ratnadewi | Zendy; Diah ACHMADI | Zendy

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Effect of Medium pH and Light on Quinidine Production in <i>Cinchona calisaya</i> Wedd. Endophytic Fungi

Author(s) -

Indriana Rahmawati,

Gayuh Rahayu,

Diah Ratnadewi,

Diah ACHMADI

Publication year - 2020

Publication title -

turkish journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.241

H-Index - 14

eISSN - 2148-6247

pISSN - 1304-530X

DOI - 10.4274/tjps.galenos.2020.35761

Subject(s) - quinidine , plant use of endophytic fungi in defense , chemistry , botany , biology , pharmacology

Quinidine has pharmaceutical importance as an antimalarial, antiarrhythmia, antimicrobial, anticancer, antioxidant, astringent, and bitter flavoring agent. Quinidine is in high demand, yet its production from the bark of the quina tree ( Cinchona calisaya ) is limited. Quinidine production from quina tree fungal endophytes, namely Aspergillus sydowii , Diaporthe sp., Diaporthe lithicola , Fusarium oxysporum , and F. solani is lower than the quinidine content of the tree bark. This study attempted to increase quinidine production from these fungi. This research aimed to determine the optimum culture conditions for quinidine production from endophytic fungi.

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