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Assessment of <i>In Vitro</i> Antigenotoxic Effect of <i>Nigella Sativa</i> Oil
Author(s) -
M. Zor,
Elçin Latife ASLAN
Publication year - 2020
Publication title -
turkish journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.241
H-Index - 14
eISSN - 2148-6247
pISSN - 1304-530X
DOI - 10.4274/tjps.galenos.2020.09471
Subject(s) - nigella sativa , genotoxicity , micronucleus test , micronucleus , traditional medicine , in vivo , pharmacology , chemistry , biology , toxicology , toxicity , medicine , microbiology and biotechnology , organic chemistry
Cyclophosphamide (CP) is an alkylating agent widely used as an antineoplastic and immunosuppressive agent. The genotoxicity of CP has been studied in a variety of in vivo and in vitro systems and is routinely used as a positive control in genotoxicity tests. Traditional medicine Nigella sativa L., ( N. sativa ), Ranunculaceae family, especially in the Eastern Mediterranean countries, especially in many countries, and is widely used in many countries as a spice and folk medicine since the time of Dioscorides used as a plant. In this study, it was aimed to show the protective effects of N. sativa oil at different concentrations against the genotoxic effects of CP by micronucleus test.

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