Evaluation of Lactose-Based Direct Tableting Agents’ Compressibility Behavior Using a Compaction Simulator | Zendy

Yıldız Özalp | Zendy; Motunrayo M. ONAYO | Zendy; Nailla Jiwa | Zendy

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Evaluation of Lactose-Based Direct Tableting Agents’ Compressibility Behavior Using a Compaction Simulator

Author(s) -

Yıldız Özalp,

Motunrayo M. ONAYO,

Nailla Jiwa

Publication year - 2019

Publication title -

turkish journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.241

H-Index - 14

eISSN - 2148-6247

pISSN - 1304-530X

DOI - 10.4274/tjps.galenos.2019.94840

Subject(s) - tableting , compressibility , compaction , materials science , lactose , compression (physics) , angle of repose , composite material , mineralogy , analytical chemistry (journal) , chromatography , chemistry , thermodynamics , organic chemistry , physics

A compaction simulator (CS) is a single-punch instrument that records data during the powder compaction process. The aim of the study was to determine the behavior of lactose-based direct tableting agents (DTAs) by CS. The data recorded were used to evaluate the flowability and compressibility of powders. The focus of the study was on comparing the compressibility of StarLac ® [alpha lactose monohydrate (85%) and white maize starch (15%)] and FlowLac ® 100 (spray-dried alpha lactose monohydrate) in order to make tablets containing poorly flowable paracetamol.

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