Cytotoxic, Genotoxic, and Apoptotic Effects of Nickel Oxide Nanoparticles in Intestinal Epithelial Cells | Zendy

Mahmoud Abudayyak | Zendy; Elif Güzel Meydanlı | Zendy; Gül Özhan | Zendy

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Cytotoxic, Genotoxic, and Apoptotic Effects of Nickel Oxide Nanoparticles in Intestinal Epithelial Cells

Author(s) -

Mahmoud Abudayyak,

Elif Güzel Meydanlı,

Gül Özhan

Publication year - 2020

Publication title -

turkish journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.241

H-Index - 14

eISSN - 2148-6247

pISSN - 1304-530X

DOI - 10.4274/tjps.galenos.2019.76376

Subject(s) - apoptosis , nickel oxide , toxicity , non blocking i/o , nanotoxicology , dna damage , chemistry , viability assay , oxidative damage , programmed cell death , cytotoxicity , in vitro , biophysics , microbiology and biotechnology , biology , oxidative stress , biochemistry , dna , organic chemistry , catalysis

The superior properties of nickel oxide-nanoparticles (NiO-NPs) have led to their wide use in various fields. However, there is little comprehensive knowledge about their toxicity, especially after oral exposure. The toxic effect of NiO-NPs of mean size 15.0 nm was investigated in Caco-2 (human intestinal epithelial) cells as no study has been performed on their intestinal toxicity.

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