Screening of Sacrificial Excipients for Arresting Devitrification of Itraconazole from Solid Dispersion | Zendy

Bhargavi M. Patel | Zendy; Mukesh Gohel | Zendy; Vaishali Thakkar | Zendy; Lalji Baldaniya | Zendy; Ruby R. Christian | Zendy; Tejal Gandhi | Zendy

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Screening of Sacrificial Excipients for Arresting Devitrification of Itraconazole from Solid Dispersion

Author(s) -

Bhargavi M. Patel,

Mukesh Gohel,

Vaishali Thakkar,

Lalji Baldaniya,

Ruby R. Christian,

Tejal Gandhi

Publication year - 2019

Publication title -

turkish journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.241

H-Index - 14

eISSN - 2148-6247

pISSN - 1304-530X

DOI - 10.4274/tjps.galenos.2018.54871

Subject(s) - dissolution , materials science , crystallinity , factorial experiment , chemical engineering , amorphous solid , dispersion (optics) , chromatography , dissolution testing , itraconazole , pharmaceutics , dosage form , poloxamer , biomedical engineering , chemistry , composite material , polymer , mathematics , organic chemistry , pharmacology , medicine , biopharmaceutics classification system , statistics , antifungal , dermatology , optics , engineering , physics , copolymer

The aim of the present investigation was to develop a solid dispersion of itraconazole (ITR) using sacrificial excipients like pregelatinized starch and spray-dried lactose alongside hydroxypropyl methylcellulose and Poloxamer 188, thereby arresting the conversion of the amorphous form of ITR to crystalline form, and to assess the dissolution stability of an amorphous form of the drug during short-term storage.

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