Open Access<i>In Vitro</i> Activities of the Cationic Steroid Antibiotics CSA-13, CSA-131, CSA-138, CSA-142, and CSA-192 Against Carbapenem-resistant <i>Pseudomonas aeruginosa</i>
Author(s) -
Çagla Bozkurt-Güzel,
Nevin Meltem AVCI,
Paul B. Savage
Publication year - 2020
Publication title -
turkish journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2148-6247
pISSN - 1304-530X
DOI - 10.4274/tjps.galenos.2018.26566
Subject(s) - colistin , pseudomonas aeruginosa , antimicrobial , minimum inhibitory concentration , antibiotics , meropenem , microbiology and biotechnology , in vivo , pharmacology , carbapenem , in vitro , minimum bactericidal concentration , polymyxin , chemistry , bacteria , antibiotic resistance , medicine , biology , biochemistry , genetics
Pseudomonas aeruginosa is an important opportunistic pathogen that is difficult to treat because of the antibiotic resistance that has developed in recent years. Increasing carbapenem resistance has led to a rise in hospital infections caused by this bacterium. As a result, researchers have begun to search for new molecules. Ceragenins are the general name for membrane-acting cationic steroid antimicrobial molecules that have activity similar to that of antimicrobial peptides. In this study, we investigated the in vitro activities of the cationic steroid antibiotics (CSAs) CSA-13, CSA-131, CSA-138, CSA-142, CSA-192, and colistin on carbapenem-resistant Pseudomonas aeruginosa (CRPA).
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