Open AccessDesign and <i>In Vitro</i> Evaluation of Eudragit-Based Extended Release Diltiazem Microspheres for Once- and Twice-Daily Administration: The Effect of Coating on Drug Release Behavior
Author(s) -
Noushin Bolourchian,
Maryam Bahjat
Publication year - 2019
Publication title -
turkish journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.241
H-Index - 14
eISSN - 2148-6247
pISSN - 1304-530X
DOI - 10.4274/tjps.galenos.2018.24861
Subject(s) - particle size , microsphere , diltiazem hydrochloride , materials science , coating , emulsion , dissolution , controlled release , chemistry , chemical engineering , chromatography , nanotechnology , diltiazem , calcium , organic chemistry , metallurgy , engineering
The aim of this investigation was to develop an extended release formulation of diltiazem hydrochloride (DL) for once- and twice-daily administration, based on Eudragit (Eud) RL and RS microspheres using emulsion solvent evaporation.
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