English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective: Stress and glucocorticoid drugs disrupts the hypothalamic–pituitary–adrenal axis that is one major causes of depression. The benefits of probiotics may extend to systems beyond the gastrointestinal tract; i.e. the central nervous system. Thus, a synbiotic (probiotic+prebiotic) mixture effect was investigated on dexamethasone (Dex) and stress induced depression. Methods: Male albino mice were used, the forced swimming test (FST) measured despair, while sucrose preference test measured anhedonia. The synbiotic regimen (12.5 × 106 CFU) was inserted in drinking water for 7 days. Dex was administered subcutaneously either single-dose on the test day or for 7 days. Water avoidance stress (WAS) induction, 1 hour each day for 4 days. Results: Drinking synbiotic reduced the immobility time during FST (54±7 sec vs, 111±6 sec water group, p<0.001). Dex injection significantly increased the immobility time (singledose=166±6 sec, and 7 day=174±9 sec) compared to the control groups, while adding synbiotic to their drink reduced it (single dose= 81 ± 6.6 sec, and 7 days= 84 ± 14 sec), indicating that synbiotic reversed Dex induced depression. WAS increased immobility time (148±11 sec, vs sham 99±6 sec, p<0.001) in FST test, by adding the synbiotic treatment following WAS, the immobility time decreased (81 ± 6.5 sec).The synbiotic groups also had a higher percentage of sucrose preference. Conclusion: The synbiotic mixture prevented the effects of WAS, acute or sub-acute Dex induced depression in mice. Therefore, probiotics might be useful and safe supplements to prevent depression related to stress or glucocorticoid therapies that deserves further evaluation.

A synbiotic mixture ameliorated depressive behavior induced by dexamethasone or water avoidance stress in mice model