Effect of the Lipid Peroxidation Product 4-Hydroxynonenal on Neuroinflammation in Microglial Cells: Protective Role of Quercetin and Monochloropivaloylquercetin | Zendy

Ahmet Cumaoğlu | Zendy; Asli Ozge Agkaya | Zendy; Zehra Ozkul | Zendy

Open Access

Effect of the Lipid Peroxidation Product 4-Hydroxynonenal on Neuroinflammation in Microglial Cells: Protective Role of Quercetin and Monochloropivaloylquercetin

Author(s) -

Ahmet Cumaoğlu,

Asli Ozge Agkaya,

Zehra Ozkul

Publication year - 2018

Publication title -

turkish journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.241

H-Index - 14

eISSN - 2148-6247

pISSN - 1304-530X

DOI - 10.4274/tjps.58966

Subject(s) - 4 hydroxynonenal , nitric oxide synthase , lipid peroxidation , keap1 , chemistry , oxidative stress , nicotinamide adenine dinucleotide phosphate , nitric oxide , cytokine , western blot , microbiology and biotechnology , heme oxygenase , biochemistry , biology , transcription factor , heme , immunology , enzyme , organic chemistry , oxidase test , gene

The lipid peroxidation-derived aldehyde 4-hydroxynonenal (HNE) has been implicated in a number of oxidative stress-induced inflammatory pathologies such as neurodegenerative diseases and aging. In this regard, we investigated the effects of HNE on neuroinflammatory responses by measuring cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) induction with cytokine production. In addition, we measured nuclear factor erythroid 2-related factor 2 (Nrf-2)/Kelch-like ECH-associated protein 1 (Keap1) signaling proteins, and antioxidant enzymes heme oxygenase-1 (HO-1) and nicotinamide adenine dinucleotide phosphate dehydrogenase, quinone 1 (NQO1), and compared the results with quercetin and monochloropivaloylquercetin (MPQ) pretreated microglial cells.

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