Protective Effects of Ursolic Acid in the Kidneys of Diabetic Rats | Zendy

Merve Bacanlı | Zendy; Sevtap Aydın | Zendy; Hatice Gül Anlar | Zendy; Tuğbagül Çal | Zendy; Ülkü Ündeğer Bucurgat | Zendy; Nuray Arı | Zendy; Arif Ahmet Başaran | Zendy; Nurşen Başaran | Zendy

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Protective Effects of Ursolic Acid in the Kidneys of Diabetic Rats

Author(s) -

Merve Bacanlı,

Sevtap Aydın,

Hatice Gül Anlar,

Tuğbagül Çal,

Ülkü Ündeğer Bucurgat,

Nuray Arı,

Arif Ahmet Başaran,

Nurşen Başaran

Publication year - 2018

Publication title -

turkish journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.241

H-Index - 14

eISSN - 2148-6247

pISSN - 1304-530X

DOI - 10.4274/tjps.49469

Subject(s) - ursolic acid , oxidative stress , diabetes mellitus , antioxidant , glutathione , streptozotocin , chemistry , pharmacology , comet assay , kidney , dna damage , endocrinology , enzyme , biochemistry , medicine , dna , chromatography

Diabetes, a heteregenous metabolic and chronic disease, is a growing health problem in most countries. It has been claimed that diabetes is associated with the increased formation of free radicals and decreased in antioxidant potential. Oxidative stress formed in diabetes may cause DNA damage in the tissues. Ursolic acid, a well-known pentacylic triterpene, is commonly used in traditional Chinese medicine due to its beneficial health effects such as antioxidant, anticancer, and antiulcer properties. The aim of this study was to investigate the effects of ursolic acid in the kidneys of Wistar albino rats with streptozotocin-induced diabetes.

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