Formulation and optimization of gentamicin hydrogel infused with tetracarpidium conophorum extract via Central composite design for topical delivery | Zendy

Margaret O. Ilomuanya | Zendy; Andrew Nosakhare Amenaghawon | Zendy; Joy Odimegwu | Zendy; Omotunde Okubanjo | Zendy; Chinelo Aghaizu | Zendy; Oluwatobiloba Adeyinka | Zendy; Thomas Akimien | Zendy; Tolulope Ajayi | Zendy

Open Access

Formulation and optimization of gentamicin hydrogel infused with tetracarpidium conophorum extract via Central composite design for topical delivery

Author(s) -

Margaret O. Ilomuanya,

Andrew Nosakhare Amenaghawon,

Joy Odimegwu,

Omotunde Okubanjo,

Chinelo Aghaizu,

Oluwatobiloba Adeyinka,

Thomas Akimien,

Tolulope Ajayi

Publication year - 2018

Publication title -

turkish journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.241

H-Index - 14

eISSN - 2148-6247

pISSN - 1304-530X

DOI - 10.4274/tjps.33042

Subject(s) - permeation , factorial experiment , central composite design , response surface methodology , chemistry , chromatography , linear regression , design of experiments , mathematics , statistics , membrane , biochemistry

Response surface methodology coupled with statistically designed experiments has been found to be very useful in optimising multivariable processes. The aim of this study was to evaluate the influence of two independent variables, a ratio of permeation enhancers/antioxidants (transcutol and ethanolic extract of tetracarpidium conophorum EETC) and stirring rate, on the flux and permeation of gentamicin hydrogel.

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