Flavin Containing Monooxygenases and Metabolism of Xenobiotics | Zendy

Rahman Başaran | Zendy; Benay CanEke | Zendy

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Flavin Containing Monooxygenases and Metabolism of Xenobiotics

Author(s) -

Rahman Başaran,

Benay CanEke

Publication year - 2017

Publication title -

turkish journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.241

H-Index - 14

eISSN - 2148-6247

pISSN - 1304-530X

DOI - 10.4274/tjps.30592

Subject(s) - monooxygenase , flavin containing monooxygenase , xenobiotic , drug metabolism , biology , cytochrome p450 , flavin group , enzyme , computational biology , biochemistry

This review summarizes recent information concerning the pharmacological and toxicological significance of the flavin-containing monooxygenases (FMOs). FMOs are a family of microsomal enzymes involving in the oxygenation of certain xenobiotics and drugs containing nucleophilic heteroatoms. The activities of FMOs in drug metabolism and their relationships with diseases are the areas of research requiring further exploration. Future studies on FMOs may provide considerable information about the pathophysiology of diseases and the information related to this enzyme family may be important for drug designs in future.

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