Effect of Aerial Parts and Root Extracts from Four Ferulago Species on Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats

Objectives: The extracts of Ferulago species are used as an aphrodisiacs in Turkey so we aimed to demonstrate in vivo and in vitro the relaxant effect of four Ferulago species extracts on corpus cavernosum (CC). Materials and Methods: A total of 30 adult male Sprague-Dawley rats were divided into control and diabetic group which were induced by single intraperitoneal injection of 40 mg/kg of Streptozotocin. In vivo erectile responses were utilized by the stimulation of cavernosal nerves and repeated after intracavernosal injection of extracts in rats and datas were expressed as intracavernosal pressure (ICP)/ mean arterial pressure (MAP) and total ICP. The relaxant and contractile responses of CC strips were analyzed in the presence or absence of extracts. Results: It was found that extracts were active both control and diabetic rats. The extracts (especially, methanol extract of root from Ferulago bracteata)-induced maximum relaxation responses (98.30 ± 2.6%) were decreased after incubation with L-NAME (44.8 ± 1.8). ODQ, soluble guanylate cyclase inhibitor inhibited 77% of extracts-induced maximum relaxation in CC from control rats. un co rre ted pr oo f