Mapping the impact of polar aprotic solvent on microstructure and dynamic phase transition in glycerol monooleate/oleic acid system | Zendy

Marzooka Kazi-Chishti | Zendy; Mohammed Hassan Dehghan | Zendy

Open Access

Mapping the impact of polar aprotic solvent on microstructure and dynamic phase transition in glycerol monooleate/oleic acid system

Author(s) -

Marzooka Kazi-Chishti,

Mohammed Hassan Dehghan

Publication year - 2019

Publication title -

turkish journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.241

H-Index - 14

eISSN - 2148-6247

pISSN - 1304-530X

DOI - 10.4274/tjps.26096

Subject(s) - polar , oleic acid , glycerol , microstructure , solvent , phase (matter) , phase transition , chemistry , materials science , chemical engineering , organic chemistry , thermodynamics , physics , crystallography , engineering , biochemistry , astronomy

Objective: The impact of incorporating a polar aprotic solvent, dimethyl sulfoxide (DMSO) to glycerol monooleate (GMO)/ oleic acid (OA) system was evaluated briefly, on purpose to map its influence on gel microstructure and dynamic phase transition in controlling performance of polyene antifungal drug delivery system. Methods: An in-situ gelling fluid precursor system (IGFPS) exhibiting inverse lyotropic liquid crystalline (LLC) phases was developed by simple solution addmixture method. Polarized light microscopy (PLM), small angle X-ray scattering (SAXS), Differential scanning calorimeter (DSC) and oscillatory rheological assessments were performed to ascertain microstructural modulations. The developed system was examined for minimum gelling volume, gelling time, swelling behavior, mucoadhesion, in-vitro antifungal activity and in-vitro drug release. Results: SAXS study identifies coexistence of Im3m cubic phase with HCP P63/mmc un co rre ct d p roo f

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