Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia | Zendy

Yaran Koban | Zendy; Hatice Köse Özlece | Zendy; Orhan Ayar | Zendy; Mustafa Koç | Zendy; Hüseyin Tuğrul Çelik | Zendy; Zeliha Yazar | Zendy; Ayşe Burcu | Zendy

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Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia

Author(s) -

Yaran Koban,

Hatice Köse Özlece,

Orhan Ayar,

Mustafa Koç,

Hüseyin Tuğrul Çelik,

Zeliha Yazar,

Ayşe Burcu

Publication year - 2016

Publication title -

turkish journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.654

H-Index - 10

eISSN - 2147-2661

pISSN - 1300-0659

DOI - 10.4274/tjo.80557

Subject(s) - mantle cell lymphoma , medicine , hepatosplenomegaly , cerebrospinal fluid , pathology , lymphoma , magnetic resonance imaging , biopsy , radiology , disease

A 72-year-old woman presented with acute onset of double vision, bilateral complete blepharoptosis, and nearly complete ophthalmoplegia. Orbital and brain magnetic resonance imaging were normal. Further investigation revealed bicytopenia with hepatosplenomegaly. Liver biopsy revealed mantle cell lymphoma. Cytology later showed the presence of mantle cells in cerebrospinal fluid analysis. Her ophthalmoplegia improved from her first cycle of systemic and intrathecal chemotherapy. To the best of our knowledge, this is the second case in the literature of mantle cell lymphoma with central nervous system involvement presenting with ophthalmoplegia. This symptom should be considered one of the initial signs of mantle cell lymphoma.

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