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To report a case series with topical anesthetic abuse and to define the clinical progression of the disease. Six eyes of three topical anesthetic\udabuser patients with various corneal abnormalities are reviewed. Signs of the disease are presented in order to document the natural\udprogression of the disease. A report was filed to the General Directorate of Pharmaceuticals and Pharmacy, Ministry of Health, Ankara,\udTurkey describing the outcome of uncontrolled use of topical anesthetic. Topical anesthetic abuse can result in serious corneal complications\udsuch as corneal epithelium defect, ring keratitis, stromal infiltrate, hypopyon, superficial and deep corneal vascularization, corneal\udlysis, and at last spontaneous perforation. The General Directorate of Pharmaceuticals and Pharmacy issued that topical anesthetics can\udonly be prescribed by an ophthalmologist up to four boxes a month, the prescription must be kept for one, year and criminal action will\udbe taken against pharmacies disregarding these provisions. (Turk J Ophthalmol 2013; 43: 289-93

Topical Anesthetic Abuse Keratopathy and its Clinical Progression