Çeşitli Nedenlere Bağlı Göz Yüzeyi Sorunlarında Topikal Otolog Serum Damla Uygulamasının Epitelizasyona Etkisi ve Güvenilirliği

Pur po se: To evaluate the effect of autologous serum application on epithelization in the treatment of ocular surface disorders in hard\udcases and its safety.\udMa te ri al and Met hod: Patients with serious ocular surface disorders, unresponsive to conventional treatment were recruited. Clinical\udfeatures of retrospective cohort of patients who were prescribed serum drops are presented. From July 2007 to January 2010, 31 eyes of 21\udpatients, who were given autologous serum eye drops, were included into the study. Clinical examination included epithelial changes, rose\udbengal/lissamine green staining, fluorescein staining, and tear film break-up time. A history of systemic disease was recorded together with\udsystemic medications used. A complete ocular history was also obtained.\udRe sults: Autologous serum was used in 7 patients with delayed epithelization after penetrating keratoplasty, in 4 patients with epithelial\uddisturbances secondary to keratitis, in 2 patients with alkali burns, in 3 patients with Stevens-Johnson syndrome, in 1 patient with ligneous\udconjunctivitis, in 1 patient with epidermolysis bullosa, in 1 patient with corneal burn with hot water, and in 2 patients with Sjogren\udsyndrome. The female:male ratio was 13:8. The mean age was 36.23±24.80 standard deviation (range: 7 months-87 years). No significant\udsight-threatening complication has been observed with the use of serum drops.\udDis cus si on: Autologous serum application is safe and efficient additional therapy in the treatment of serious ocular surface problems in\uddifficult cases. (Turk J Ophthalmol 2012; 42: 336-41