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Is There a Relationship Between Use of Anti-Vascular Endothelial Growth Factor Agents and Atrophic Changes in Age-Related Macular Degeneration Patients?
Author(s) -
Süleyman Kaynak,
Mahmut Kaya,
Derya Kaya
Publication year - 2018
Publication title -
turkish journal of ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 10
eISSN - 2147-2661
pISSN - 1300-0659
DOI - 10.4274/tjo.27448
Subject(s) - macular degeneration , geographic atrophy , atrophy , medicine , vascular endothelial growth factor , neovascularization , vegf receptors , choroidal neovascularization , degeneration (medical) , pathology , ophthalmology , angiogenesis
Choroidal neovascularization due to age-related macular degeneration (AMD) is currently treated successfully with anti-vascular endothelial growth factor (VEGF) intravitreal agents. Emerging evidence suggests that anti-VEGF treatment may potentially increase development of geographic atrophy. However, there is not yet direct proof of a causal relationship between geographic atrophy and use of anti-VEGF agents in neovaskuler AMD. The aim of this review is to discuss the evidence concerning the association between anti-VEGF therapy and progression of geographic atrophy.

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