The Role of Radical Prostatectomy in the Treatment of Patients with High-Risk Prostate Cancer

High-risk prostate cancer (PCa), which is defined as PSA >20 ng/mL\udor Gleason Score (GS) >7 or ≥cT3a, accounts for up to 40% of newly\uddiagnosed cases and carries a significant risk of progression and death.\udHowever, the best management approach for patients with high-risk PCa\udis still under debate. Recently, radical prostatectomy (RP) with extended\udlymphadenectomy (LND) has become popular for the treatment of\udhigh-risk PCa with good prognosis in selected patients in the context\udof multimodal approach. However, decision should be made after all\udtreatments have been discussed by a multidisciplinary team and the\udpatient should be informed about the likelihood of a multimodal\udapproach. On the other hand, necessity of sufficient surgical expertise\udfor RP to keep the level of morbidity acceptable in high-risk PCa patients\udshould be kept in mind