Changes in Collagen Type 3, Elastin, Fibrosis and Cajal Cell in Congenital Ureteropelvic Junction Obstruction

To compare changes in collagen type 3, elastin, fibrosis and cajal cells\udthrough histopathological examination of the ureteropelvic junction (UPJ)\udsegments of pediatric and adult patients who had undergone AndersonHynes\udpyeloplasty for ureteropelvic junction obstruction (UPJO).\udMaterials and Methods\udHistopathological evaluation was made of the UPJ segments of 52 patients\udwho underwent Anderson-Hynes pyeloplasty for UPJO between January\ud2005 and January 2008. Patients were separated into 2 groups as pediatric,\udaged ≤15 years (group 1, n=10) and adult, aged >15 years (group 2, n=42).\udUPJ segments of both groups were compared histopathologically (collagen\udtype 3, elastin, fibrosis and cajal cells). Radiographic evaluations were made\udwith diuretic renogram and/or intravenous pyelography.\udResults\udMean age of group 1 patients was 8.12±2.6 years (1-12 years) and of group\ud2 patients, 38.16±5.91 years (16-62 years). Mean follow-up period was 18\udmonths (9-24 months). No statistically significant difference was determined\udbetween the groups in respect of collagen type 3, elastin, fibrosis or cajal\udcells (p>0.05).\udConclusion\udAs the pathology in the UPJ obstruction is a congenital defect, the\udhistopathology does not change with age