Identification of Novel Mutations in STAR Gene in Patients with Lipoid Congenital Adrenal Hyperplasia: A First Report from India | Zendy

V. Lakshmi | Zendy; J. B. Rajesh | Zendy; Kumar Das Dhanjit | Zendy; R Sudha | Zendy; Sanghavi Daksha | Zendy; Babu Shiny | Zendy

Open Access

Identification of Novel Mutations in STAR Gene in Patients with Lipoid Congenital Adrenal Hyperplasia: A First Report from India

Author(s) -

V. Lakshmi,

J. B. Rajesh,

Kumar Das Dhanjit,

R Sudha,

Sanghavi Daksha,

Babu Shiny

Publication year - 2013

Publication title -

journal of clinical research in pediatric endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.566

H-Index - 35

eISSN - 1308-5735

pISSN - 1308-5727

DOI - 10.4274/jcrpe.927

Subject(s) - frameshift mutation , missense mutation , medicine , congenital adrenal hyperplasia , mutation , prenatal diagnosis , genetics , gene , genetic counseling , fetus , gene mutation , pregnancy , biology

Lipoid congenital adrenal hyperplasia (LCAH), a rare disorder of steroid biosynthesis, is the most severe form of CAH. We report novel molecular findings of three unrelated infants with LCAH diagnosed at our center. A known missense mutation c.653C>T (p.A218V) and two novel mutations [premature termination c.441G>A (or p.W147X) and frameshift deletion c.del815G (or p.R272PfsX35)] were identified after complete sequencing of the STAR gene. Prenatal diagnosis was carried out for the family with mutation c.815delG by molecular testing wherein the fetus was found to be homozygous for the mutation. This is the first report of molecular diagnosis and prenatal testing for LCAH from India.

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