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The Role of Osteopontin in the Pathogenesis and Complications of Type 1 Diabetes Mellitus in Children
Author(s) -
Mohamed A. Talat,
Laila M. Sherief,
Hosam F. Elsaadany,
Anwar A. Rass,
Rabab M. Saleh,
Maha Mahmoud Hamed Sakr
Publication year - 2016
Publication title -
journal of clinical research in pediatric endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.566
H-Index - 35
eISSN - 1308-5735
pISSN - 1308-5727
DOI - 10.4274/jcrpe.3082
Subject(s) - medicine , osteopontin , microalbuminuria , endocrinology , diabetes mellitus , creatinine , type 1 diabetes , type 2 diabetes mellitus , body mass index , gastroenterology , pathogenesis
Type 1 diabetes mellitus (T1DM) is the most common chronic metabolic disorder of childhood and adolescence. Osteopontin plays a significant role in the development and progression of several autoimmune diseases. Moreover, osteopontin promotes adipose tissue inflammation, dysfunction, and insulin resistance. To investigate the levels of serum osteopontin in pediatric patients with T1DM and to explore if these levels have a role in the prediction of diabetes complications.

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