Generation of Monocyte-Derived Insulin-Producing Cells from Non-Human Primates According to an Optimized Protocol for the Generation of PCMO-Derived Insulin-Producing Cells | Zendy

J H Walter | Zendy; Ole Harder | Zendy; Fred Faendrich | Zendy; Maren Schulze | Zendy

Open Access

Generation of Monocyte-Derived Insulin-Producing Cells from Non-Human Primates According to an Optimized Protocol for the Generation of PCMO-Derived Insulin-Producing Cells

Author(s) -

J H Walter,

Ole Harder,

Fred Faendrich,

Maren Schulze

Publication year - 2014

Publication title -

journal of clinical research in pediatric endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.566

H-Index - 35

eISSN - 1308-5735

pISSN - 1308-5727

DOI - 10.4274/jcrpe.1284

Subject(s) - baboon , insulin , monocyte , spleen , endocrinology , medicine , biology

The vision of potential autologous cell therapy for the cure of diabetes encourages ongoing research. According to a previously published protocol for the generation of insulin-producing cells from human monocytes, we analyzed whether the addition of growth factors could increase insulin production. This protocol was then transferred to a non-human primate model by using either blood- or spleen-derived monocytes.

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