The Acute Effect of Erythropoietin on Mean Platelet Volume Levels during Hypoxia Reoxygenation Injury in Rats | Zendy

Constantinos Tsompos | Zendy; Constantinos Panoulis | Zendy; Konstantinos Tοutouzas | Zendy; Aggeliki Triantafyllou | Zendy; George C. Zografos | Zendy; Αpostolos Papalois | Zendy

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The Acute Effect of Erythropoietin on Mean Platelet Volume Levels during Hypoxia Reoxygenation Injury in Rats

Author(s) -

Constantinos Tsompos,

Constantinos Panoulis,

Konstantinos Tοutouzas,

Aggeliki Triantafyllou,

George C. Zografos,

Αpostolos Papalois

Publication year - 2016

Publication title -

medical bulletin of haseki

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.113

H-Index - 4

eISSN - 2147-2688

pISSN - 1302-0072

DOI - 10.4274/haseki.3370

Subject(s) - erythropoietin , hypoxia (environmental) , platelet , mean platelet volume , medicine , anesthesia , cardiology , oxygen , chemistry , organic chemistry

Aim: This biomedical study tested the effect of erythropoietin (Epo) in rat model, especially in a hypoxia-reoxygenation one. The trend of this factor was evaluated hematologically using serum mean platelets volume (MPV) values.\udMethods: Forty rats with a mean mass 247.7 g were used. MPV values were evaluated at 60 min (for groups A and C) and at 120 min (for groups B and D) of reoxygenation. Epo was provided only in groups C and D.\udResults: Epo administration non-significantly lowered the MPV levels by 0.12% +2.13% (p=0.9513). Reoxygenation time non-significantly augmented the MPV levels by 1.37%+2.11% (p=0.4873). However, Epo administration together with reoxygenation time non-significantly reduced the MPV levels by 0.27%+0.92% (p=0.7585).\udConclusion: Epo administration had a non-significant short-time decline effect on MPV levels

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