Approach to DRESS Syndrome Associated with Allopurinol Use in a Geriatric Patient

Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) is a rare and life-threatening drug-induced hypersensitivity reaction that presents with skin rashes, hematological abnormalities such as eosinophilia and atypical lymphocytosis, lymphadenopathy, and involvement of internal organs such as the liver, kidney, and lung. Here, we present the case of a 65-year-old man diagnosed with DRESS syndrome after allopurinol therapy. This case highlights the importance of being vigilant for drug toxicity reactions that may occur in older adults due to allopurinol use.