Correlation of Early Subarachnoid Hemorrhage on Serum Endothelin and von Willebrand Factor with Clinical and Radiological Parameters

Öz 100 Bagcilar Med Bull 2020;5(3):100-106 DO I: 10.4274/BMB.galenos.2020.06.22 Serkan Kitiş1, Meliha Gündağ Papaker1, Eray Metin Güler2 1Bezmialem Vakıf University Faculty of Medicine, Department of Neurosurgery, İstanbul, Turkey 2Bezmialem Vakıf University Faculty of Medicine, Department of Biochemistry, İstanbul, Turkey ORIGINAL RESEARCH Address for Correspondence: Serkan Kitiş, Bezmialem Vakıf University Faculty of Medicine, Department of Neurosurgery, İstanbul, Turkey E-mail: serkankitis@yahoo.com ORCID: orcid.org/0000-0002-9119-5899 Received: 15.06.2020 Accepted: 28.07.2020 Cite this article as: Kitiş S, Gündağ Papaker M, Güler EM. Correlation of Early Subarachnoid Hemorrhage on Serum Endothelin and von Willebrand Factor with Clinical and Radiological Parameters. Bagcilar Med Bull 2020;5(3):100-106 ©Copyright 2020 by the Health Sciences University Turkey, Bagcilar Training and Research Hospital Bagcilar Medical Bulletin published by Galenos Publishing House. there was an increasing rate of endothelin and vWF values as the GCS score decreased (r=-0.465 p=0.004, r=-0.465 p=0.004). There was also a significant relationship between FS score and endothelin and vWF values. It was observed that as FS score increased, endothelin, and vWF values also increased (r=0.571, p<0.001, r=0.538, p=0.001). Conclusion: Evidence suggests that inflammation plays an important role in the acute phases of aneurysmal SAH-related neural damage. Our study showed that serum endothelin and vWF levels increased in the first day of bleeding in aneurysmal SAH patients and that they were associated with the GCS and FS scores.