Evaluation of Liver Enzymes, Hemogram and Lipid Parameters in Acne Patients Using Systemic Isotretinoin

Yazışma Adresi/Address for Correspondence: Dr. Gül Aslıhan Çakır Akay, Ufuk Üniversitesi Tıp Fakültesi, Dr. Rıdvan Ege Hastanesi, Deri ve Zührevi Hastalıkları Kliniği, Ankara, Türkiye Tel.: +90 312 204 41 79 E-posta: aslihancakir@gmail.com ORCID ID: orcid.org/0000-0003-2310-1763 Geliş Tarihi/Received: 21.05.2018 Kabul Tarihi/Accepted: 25.07.2018 Objectives: Systemic isotretinoin (SI) is the most effective agent in the treatment of resistant acne vulgaris, affecting all four pathogenetic factors. However, laboratory abnormalities caused by SI have been reported for many years. Current studies indicate that these disorders may be temporary transient changes, so that monthly monitoring of laboratory parameters is not required during routine SI therapy. In this study, it was aimed to evaluate changes in hemogram, lipid parameters and liver function tests in acne patients who received SI treatment. Materials and Methods: This study consisted of 52 patients (18-35 years old) diagnosed with severe, nodular acne that leaves scars and resistant to 4 months systematic antibiotics treatment. Patients received SI treatment with 0.5-1 mg/kg dose, in total 120-150 mg cumulative dose. Hemogram, liver enzyme and lipid parameters are recorded before treatment and 3and 6-month visits. Results: When the results of before treatment, 3and 6-month visits are statistically compared, a significant increase is observed in the values of gamma glutamyl transferase, total cholesterol, triglyceride, low density lipoprotein values and a significant decrease is observed in white sphere values. Conclusion: According to our study findings, the treatment of SI causes changes the white sphere, gamma glutamyl transferase, total cholesterol, triglyceride, low density lipoprotein levels. At the same time all these changes are within the normal reference value limits. Therefore, during treatment, instead of routine monthly observation, we propose a proper diet and a more intermittent follow-up.