Open AccessNon-Oral Treatment with Ivermectin for Disseminated Strongyloidiasis
Author(s) -
Dahlene N. Fusco,
Jennifer A. Downs,
Michael J. Satlin,
Meera Pahuja,
Liz G. Ramos,
Philip S. Barie,
Lawrence Fleckenstein,
Henry W. Murray
Publication year - 2010
Publication title -
the american journal of tropical medicine and hygiene
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.015
H-Index - 151
eISSN - 1476-1645
pISSN - 0002-9637
DOI - 10.4269/ajtmh.2010.10-0258
Subject(s) - ivermectin , strongyloidiasis , medicine , dosing , anthelmintic , antiparasitic agent , intensive care medicine , dermatology , surgery , immunology , pharmacology , helminths , veterinary medicine
Critically ill patients with disseminated strongyloidiasis may not be candidates for oral treatment. We report four patients with disseminated strongyloidiasis, believed to be unable to absorb oral therapy, who were treated with ivermectin by rectal and/or subcutaneous administration. Obtaining subcutaneous ivermectin and dosing it appropriately is a challenge. These cases underscore the need for improved access to subcutaneous ivermectin and more pharmacological data to guide use of this treatment approach.