Open AccessHuman Antibody Response to Anopheles gambiae Saliva: An Immuno-Epidemiological Biomarker to Evaluate the Efficacy of Insecticide-Treated Nets in Malaria Vector Control
Author(s) -
Papa M. Drame,
Anne Poinsig,
Patrick Besnard,
Jacques Le Mire,
Maria Adelaide Dos-Santos,
Cheikh Sow,
Sylvie Cornélie,
V. Foumane,
Jean-Claude Toto,
Mbacké Sembène,
Denis Boulanger,
François Simondon,
Filomeno Fortes,
Pierre Coriat,
Franck Remoué
Publication year - 2010
Publication title -
the american journal of tropical medicine and hygiene
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.015
H-Index - 151
eISSN - 1476-1645
pISSN - 0002-9637
DOI - 10.4269/ajtmh.2010.09-0684
Subject(s) - malaria , anopheles gambiae , vector (molecular biology) , saliva , biology , tropical medicine , immunology , anopheles , plasmodium falciparum , environmental health , medicine , zoology , biochemistry , gene , recombinant dna
For the fight against malaria, the World Health Organization (WHO) has emphasized the need for indicators to evaluate the efficacy of vector-control strategies. This study investigates a potential immunological marker, based on human antibody responses to Anopheles saliva, as a new indicator to evaluate the efficacy of insecticide-treated nets (ITNs). Parasitological, entomological, and immunological assessments were carried out in children and adults from a malaria-endemic region of Angola before and after the introduction of ITNs. Immunoglobulin G (IgG) levels to An. gambiae saliva were positively associated with the intensity of An. gambiae exposure and malaria infection. A significant decrease in the anti-saliva IgG response was observed after the introduction of ITNs, and this was associated with a drop in parasite load. This study represents the first stage in the development of a new indicator to evaluate the efficacy of malaria vector-control strategies, which could apply in other arthropod vector-borne diseases.