The Propensity of Different Borrelia burgdorferi sensu stricto Genotypes to Cause Disseminated Infections in Humans | Zendy

Daniel E. Dykhuizen | Zendy; Dustin Brisson | Zendy; Sabina Sandigursky | Zendy; Gary P. Wormser | Zendy; John Nowakowski | Zendy; Robert B. Nadelman | Zendy; Ira Schwartz | Zendy

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The Propensity of Different Borrelia burgdorferi sensu stricto Genotypes to Cause Disseminated Infections in Humans

Author(s) -

Daniel E. Dykhuizen,

Dustin Brisson,

Sabina Sandigursky,

Gary P. Wormser,

John Nowakowski,

Robert B. Nadelman,

Ira Schwartz

Publication year - 2008

Publication title -

american journal of tropical medicine and hygiene

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.015

H-Index - 151

eISSN - 1476-1645

pISSN - 0002-9637

DOI - 10.4269/ajtmh.2008.78.806

Subject(s) - sensu stricto , borrelia burgdorferi , biology , borrelia , genotype , microbiology and biotechnology , virology , zoology , antibody , genetics , gene

Lineages of Borrelia burgdorferi, the bacterium that causes Lyme disease, can be characterized by distinct alleles at the outer surface protein C (ospC) locus. The lineages marked by ospC genotypes have been shown to be differentially invasive in different species of mammals, including humans; genotypes A, B, I, and K effectively disseminate to human blood and cerebrospinal fluid. In this report, we extend the sample of genotypes isolated from human blood to include genotypes N, H, C, M, and D, and rank each by their probability of disseminating from ticks to the blood of humans. Our results demonstrate that only some genotypes of B. burgdorferi present in ticks have a high propensity to disseminate in humans.

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