Open AccessBCG VACCINE EFFECTIVENESS AGAINST BURULI ULCER: A CASE-CONTROL STUDY IN BENIN
Author(s) -
Fabienne Nackers,
Michèle Dramaix,
Roch Christian Johnson,
Claude Zinsou,
Annie Robert,
Elisa de Biurrun Bakedano,
Judith R. Glynn,
Françoise Portaels,
René Tonglet
Publication year - 2006
Publication title -
american journal of tropical medicine and hygiene
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.015
H-Index - 151
eISSN - 1476-1645
pISSN - 0002-9637
DOI - 10.4269/ajtmh.2006.75.768
Subject(s) - buruli ulcer , medicine , mycobacterium ulcerans , vaccination , confidence interval , socioeconomic status , bcg vaccine , environmental health , public health , immunology , population , disease , pathology
BCG remains the only possible prophylactic intervention against Buruli ulcer (BU). Estimating its public health impact on BU control is an important issue. We conducted a case-control study to investigate the vaccine effectiveness of routine BCG vaccine against BU in southern Benin. From August 2002 to August 2003, BCG vaccination status was obtained for 279 clinically diagnosed BU cases and 988 age- and sex-matched neighborhood controls. BCG coverage, which was estimated by the presence of a scar or a vaccination record, was 64.5% in cases and 67.2% in controls. There was no evidence of a protective effect of routine BCG vaccination against BU in southern Benin (vaccine effectiveness adjusted for socioeconomic status = 12%, 95% confidence interval = -24% to 37%).
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