RAPID ONSET OF TRANSMISSION-REDUCING ANTIBODIES IN JAVANESE MIGRANTS EXPOSED TO MALARIA IN PAPUA, INDONESIA | Zendy

Teun Bousema | Zendy; Will Roeffen | Zendy; M. van der Kolk | Zendy; Sake J. de Vlas | Zendy; MARGA VAN DE VEGTE-BOLMER | Zendy; Michael J. Bangs | Zendy; Karina Teelen | Zendy; Liliana Kurniawan | Zendy; Jason D. Maguire | Zendy; J. Kevin Baird | Zendy; Robert W. Sauerwein | Zendy

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RAPID ONSET OF TRANSMISSION-REDUCING ANTIBODIES IN JAVANESE MIGRANTS EXPOSED TO MALARIA IN PAPUA, INDONESIA

Author(s) -

Teun Bousema,

Will Roeffen,

M. van der Kolk,

Sake J. de Vlas,

MARGA VAN DE VEGTE-BOLMER,

Michael J. Bangs,

Karina Teelen,

Liliana Kurniawan,

Jason D. Maguire,

J. Kevin Baird,

Robert W. Sauerwein

Publication year - 2006

Publication title -

american journal of tropical medicine and hygiene

Language(s) - English

Resource type - Journals

eISSN - 1476-1645

pISSN - 0002-9637

DOI - 10.4269/ajtmh.2006.74.425

Subject(s) - biology , malaria , parasitemia , plasmodium falciparum , antibody , immunity , transmission (telecommunications) , gametocyte , immunology , seroprevalence , seroconversion , virology , odds ratio , immune system , medicine , serology , electrical engineering , engineering

Transmission of Plasmodium falciparum malaria is initiated by sexual stages in the mosquito. Anti-Pfs48/45 and anti-Pfs230 sexual stage antibodies that are ingested together with parasites can reduce parasite development and subsequently malaria transmission. Acquisition of sexual stage immunity was studied in a cohort of 102 non-immune Javanese individuals migrating to hyperendemic Papua Indonesia. Seroprevalence of antibodies against Pfs48/45 and Pfs230 and functional transmission-reducing activity (TRA) were measured upon arrival and at 6, 12, and 24 months. Asexual parasitemia and gametocytemia were assessed every two weeks. The TRA and seroreactivity increased with the number of P. falciparum infections. The longitudinally sustained association between TRA and antibodies against Pfs48/45 (odds ratio [OR] = 3.74, 95% confidence interval [CI] = 1.51-9.29) and Pfs230 (OR = 3.72, 95% CI = 1.36-10.17) suggests that functional transmission reducing immunity is acquired after limited exposure to infection.

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