ASSOCIATION OF HAPTOGLOBIN LEVELS WITH AGE, PARASITE DENSITY, AND HAPTOGLOBIN GENOTYPE IN A MALARIA-ENDEMIC AREA OF GABON | Zendy

Freya J. I. Fowkes | Zendy; Philippe Deloron | Zendy; ANITA JUSTICE | Zendy; Heather Imrie | Zendy; P Michon | Zendy; Karen P. Day | Zendy; Florence MigotNabias | Zendy; Adrian J. F. Luty | Zendy

Open Access

ASSOCIATION OF HAPTOGLOBIN LEVELS WITH AGE, PARASITE DENSITY, AND HAPTOGLOBIN GENOTYPE IN A MALARIA-ENDEMIC AREA OF GABON

Author(s) -

Freya J. I. Fowkes,

Philippe Deloron,

ANITA JUSTICE,

Heather Imrie,

P Michon,

Karen P. Day,

Florence MigotNabias,

Adrian J. F. Luty

Publication year - 2006

Publication title -

american journal of tropical medicine and hygiene

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.015

H-Index - 151

eISSN - 1476-1645

pISSN - 0002-9637

DOI - 10.4269/ajtmh.2006.74.26

Subject(s) - malaria , haptoglobin , biology , parasite hosting , genotype , abo blood group system , hemolysis , plasmodium falciparum , sickle cell trait , immunology , population , demography , medicine , gene , disease , genetics , sociology , world wide web , computer science

Haptoglobin (Hp) levels were investigated in relation to host genotype in a malaria-endemic area in Gabon. A cross-sectional study of 1-12-year-old children was conducted in the rainy season, a period of high malaria transmission, to examine this relationship. Variables that influenced Hp levels were Hp genotype, location, and age interacting with parasite density. At low parasite densities, there was a negative correlation between Hp levels and age. At higher densities, there was a positive correlation with age. This suggests that in the presence of greater parasite-induced hemolysis, older children are capable of increased production of Hp. Sickle cell trait and ABO blood group was not associated with Hp levels in this population.

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