GENETIC COMPLEXITY OF PLASMODIUM FALCIPARUM IN TWO ETHNIC GROUPS OF BURKINA FASO WITH MARKED DIFFERENCES IN SUSCEPTIBILITY TO MALARIA | Zendy

Giacomo Maria Paganotti | Zendy; Hamza A. Babiker | Zendy; David Modiano | Zendy; Sodiomon B. Sirima | Zendy; Federica Verra | Zendy; AMADOU KONATÉ | Zendy; André Lin Ouédraogo | Zendy; AMIDOU DIARRA | Zendy; Margaret J. Mackin | Zendy; M. Cóluzzi | Zendy; David Walliker | Zendy

Open Access

GENETIC COMPLEXITY OF PLASMODIUM FALCIPARUM IN TWO ETHNIC GROUPS OF BURKINA FASO WITH MARKED DIFFERENCES IN SUSCEPTIBILITY TO MALARIA

Author(s) -

Giacomo Maria Paganotti,

Hamza A. Babiker,

David Modiano,

Sodiomon B. Sirima,

Federica Verra,

AMADOU KONATÉ,

André Lin Ouédraogo,

AMIDOU DIARRA,

Margaret J. Mackin,

M. Cóluzzi,

David Walliker

Publication year - 2004

Publication title -

american journal of tropical medicine and hygiene

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.015

H-Index - 151

eISSN - 1476-1645

pISSN - 0002-9637

DOI - 10.4269/ajtmh.2004.71.173

Subject(s) - malaria , plasmodium falciparum , biology , gametocyte , ethnic group , merozoite surface protein , parasite hosting , plasmodium (life cycle) , allele , zoology , demography , immunology , genetics , gene , malaria vaccine , sociology , anthropology , world wide web , computer science

We have characterized Plasmodium falciparum genotypes among the Mossi and Fulani sympatric ethnic groups in villages in Burkina Faso during the rainy season. Differences in clinical malaria presentation and in immune responses to malaria occur between the two groups. Asexual parasite rate, density, and gametocyte rate were higher among the Mossi than the Fulani. There was no difference in frequencies of alleles of the P. falciparum merozoite surface protein 1 (msp-1), msp-2, and glutamate-rich protein (glurp) genes among the parasites in each group. However, there were significant differences in the mean number of P. falciparum clones in the two populations, with there being more in the Mossi than in the Fulani. This effect was especially marked in older children. These differences can most probably be attributed to genetic differences in immune responsiveness to malaria between the two ethnic groups.

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