SHORT REPORT: REQUIREMENT OF B CELLS FOR DELAYED TYPE HYPERSENSITIVITY–LIKE PATHOLOGY AFTER SECONDARY INFECTION WITH LEISHMANIA MAJOR IN RESISTANT C57BL/6 MICE | Zendy

Gregory K. DeKrey | Zendy; Jeremy J. Jones | Zendy; Moustapha Mbow | Zendy; Cláudia Brodskyn | Zendy; Richard G. Titus | Zendy

Open Access

SHORT REPORT: REQUIREMENT OF B CELLS FOR DELAYED TYPE HYPERSENSITIVITY–LIKE PATHOLOGY AFTER SECONDARY INFECTION WITH LEISHMANIA MAJOR IN RESISTANT C57BL/6 MICE

Author(s) -

Gregory K. DeKrey,

Jeremy J. Jones,

Moustapha Mbow,

Cláudia Brodskyn,

Richard G. Titus

Publication year - 2003

Publication title -

american journal of tropical medicine and hygiene

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.015

H-Index - 151

eISSN - 1476-1645

pISSN - 0002-9637

DOI - 10.4269/ajtmh.2003.69.481

Subject(s) - leishmania major , immunology , leishmania , biology , interferon gamma , ratón , hypersensitivity reaction , c57bl/6 , interferon , delayed hypersensitivity , parasite hosting , pathology , virology , medicine , immune system , world wide web , computer science

B cell-deficient C57B1/6 (microMT) mice were resistant to Leishmania major after both primary and secondary parasite challenge. However, unlike in wild-type mice, secondary infection in microMT mice was not accompanied by a marked delayed type hypersensitivity-like response, and interferon-gamma (IFN-gamma) levels were approximately half of those in wild-type mice. These results suggest that B cells are involved in IFN-gamma production and the pathology of secondary infection.

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