Detection and significance of inapparent infection in Chagas disease in western Venezuela. | Zendy

N AÃ±ez | Zendy; Gladys Crisante | Zendy; Alejandra RojasMolina | Zendy; Hugo Carrasco | Zendy; Henry Parada | Zendy; Yuri Yépez | Zendy; Rafael Borges | Zendy; Palmira Guevara | Zendy; J L Ramirez | Zendy

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Detection and significance of inapparent infection in Chagas disease in western Venezuela.

Author(s) -

N AÃ±ez,

Gladys Crisante,

Alejandra RojasMolina,

Hugo Carrasco,

Henry Parada,

Yuri Yépez,

Rafael Borges,

Palmira Guevara,

J L Ramirez

Publication year - 2001

Publication title -

american journal of tropical medicine and hygiene

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.015

H-Index - 151

eISSN - 1476-1645

pISSN - 0002-9637

DOI - 10.4269/ajtmh.2001.65.227

Subject(s) - chagas disease , serology , trypanosoma cruzi , asymptomatic , antibody , biology , immunology , virology , polymerase chain reaction , trypanosomiasis , medicine , parasite hosting , biochemistry , world wide web , computer science , gene

Inapparent infections of Trypanosoma cruzi were detected in symptomless seropositive people living in close proximity, and under the same conditions of risk, to patients with acute Chagas disease. Similar infections were also detected in sera samples of people from 25 villages of western Venezuela where Chagas disease is endemic. Seropositivity in all the 1,251 studied samples was established by use of 3 serological methods (direct agglutination test, indirect immunofluorescence antibody test, and enzyme-linked immunosorbent assay). Each seropositive sample was tested for detection of anti-T. cruzi-specific immunoglobulin (Ig) M and IgG levels and specific T. cruzi infection by molecular methodology (polymerase chain reaction assay). The combined analysis of the serologic (IgM and IgG levels), molecular (specific T. cruzi DNA), and statistical findings demonstrated the existence of a different stage of T. cruzi infection in asymptomatic patients, which is suggested to be recognized as inapparent infection. Its definition, significance, and comparison with typical Chagas disease phases are presented, and its potential epidemiological importance is discussed.

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