Open AccessCase Report: Trypanosoma brucei Gambiense Human African Trypanosomiasis as the Cause of Fever in an Inpatient with Multiple Myeloma and HIV-1 Coinfection
Author(s) -
Carl Boodman,
Michael Libman,
Momar Ndao,
Cédric P. Yansouni
Publication year - 2019
Publication title -
american journal of tropical medicine and hygiene
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.015
H-Index - 151
eISSN - 1476-1645
pISSN - 0002-9637
DOI - 10.4269/ajtmh.18-0889
Subject(s) - coinfection , african trypanosomiasis , multiple myeloma , context (archaeology) , immunosuppression , trypanosomiasis , immunology , malignancy , trypanosoma brucei , medicine , concomitant , virology , neglected tropical diseases , biology , human immunodeficiency virus (hiv) , disease , gene , biochemistry , paleontology
We report the case of a 64-year-old woman found to have urban-acquired Trypanosoma brucei ( T.b. ) gambiense human African trypanosomiasis (HAT) as the cause of sustained fever starting 9 months after returning to Canada from Democratic Republic of the Congo, in the context of concomitant multiple myeloma and HIV-1 coinfection. Approaches for the management of both clinical stages of T.b. gambiense HAT are well defined for endemic settings using current diagnostics and treatments. However, few data inform the diagnosis and management of patients with bone marrow suppression from active malignancy, recent anticancer therapy, or HIV coinfection. We discuss the implications of immunosuppression for diagnosis and management of T.b. gambiense HAT.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom