Open AccessPrimaquine Dosing Errors: The Human Cost of a Pharmaceutical Anachronism
Author(s) -
Eyal Meltzer,
Lindsay R. Morrison,
Shmuel Stienlauf,
Eli Schwartz
Publication year - 2015
Publication title -
american journal of tropical medicine and hygiene
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.015
H-Index - 151
eISSN - 1476-1645
pISSN - 0002-9637
DOI - 10.4269/ajtmh.14-0109
Subject(s) - primaquine , malaria , confusion , medicine , dosing , plasmodium falciparum , plasmodium vivax , pharmacology , intensive care medicine , toxicology , chloroquine , biology , immunology , psychology , psychoanalysis
Confusion between salt/base forms of primaquine may result in malaria prophylaxis failure. During 1995-2011, there were 14 malaria cases in Israel despite primaquine primary prophylaxis. In 6/14 cases, primaquine was underdosed because of confusion between salt and base forms, including two Plasmodium falciparum cases. Primaquine labeling clarification may be lifesaving.
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