TNIK (TRAF2 and NCK interacting kinase) | Zendy

Adriana Cassaro | Zendy

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TNIK (TRAF2 and NCK interacting kinase)

Author(s) -

Adriana Cassaro

Publication year - 2020

Publication title -

atlas of genetics and cytogenetics in oncology and haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.121

H-Index - 2

ISSN - 1768-3262

DOI - 10.4267/2042/70860

Subject(s) - cancer research , traf2 , kinase , gene , microbiology and biotechnology , biology , genetics , apoptosis , tumor necrosis factor receptor

The serine/threonine kinase Traf2and Nck interacting kinase (TNIK), is a member of the germinal center kinase (GCK) family that has been reported to have an important role in the regulation of Jun N-terminal kinase pathway (JNK) activation and actin cytoskeleton. It has also been demonstrated that TNIK is an important activator of Wnt pathway, where it interacts with β-catenin/TCF4 complex, phosphorylates TCF4 inducing the transcription of Wnt target genes. In several studies, the expression of TNIK has been established to be involved in different human cancers.

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