PARP1 (poly(ADP-ribose) polymerase 1) | Zendy

Sinem Tunçer | Zendy; Kubra Kavak | Zendy

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PARP1 (poly(ADP-ribose) polymerase 1)

Author(s) -

Sinem Tunçer,

Kubra Kavak

Publication year - 2020

Publication title -

atlas of genetics and cytogenetics in oncology and haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.121

H-Index - 2

ISSN - 1768-3262

DOI - 10.4267/2042/70775

Subject(s) - parp1 , poly adp ribose polymerase , polymerase , microbiology and biotechnology , biology , genetics , chemistry , gene

PARP1 (poly(ADP-ribose) polymerase 1) is a nuclear protein involved in the regulation of various biological processes including apoptosis, DNA repair for the maintenance of genome integrity, epigenetic marking of chromatin, assembly of higher-order chromatin structures, transcriptional activation, differentiation, proliferation, and cell cycle. Particularly, due to its decisive role in several DNA repair pathways, the inhibition of PARP1 has emerged as a prominent therapeutic option in cancer treatment, by improving the efficiency of chemotherapeutics or radiation therapy.

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