FANCB (FA complementation group B) | Zendy

Sylvie van Twest | Zendy; Andrew J. Deans | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

FANCB (FA complementation group B)

Author(s) -

Sylvie van Twest,

Andrew J. Deans

Publication year - 2019

Publication title -

atlas of genetics and cytogenetics in oncology and haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.121

H-Index - 2

ISSN - 1768-3262

DOI - 10.4267/2042/70644

Subject(s) - genetics , group (periodic table) , complementation , biology , gene , chemistry , phenotype , organic chemistry

FANCB protein is a component of the Fanconi Anemia (FA) core complex needed for DNA repair. Within the core complex, FANCB forms a protein subcomplex with two other proteins, FAAP100, and an E3 RING ligase FANCL (BL100) to monoubiquitinate FANCD2 and FANCI (ID2), a process that is defective in 95% of all FA patients. FA is a rare, genetic cancer pre-disposition syndrome characterized by chromosomal instability and hypersensitivity to DNA crosslinking agents, such as those used in chemotherapy like mitomycin C (MMC) (Kennedy D'Andrea, 2006). FANCB is the only known X-linked FA gene, and mutations account for 1% of FA cases (Alter Rosenberg, 2013).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research