Pediatric T-Cell Acute Lymphoblastic Leukemia | Zendy

Mark A. Micale | Zendy

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Pediatric T-Cell Acute Lymphoblastic Leukemia

Author(s) -

Mark A. Micale

Publication year - 2018

Publication title -

atlas of genetics and cytogenetics in oncology and haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.121

H-Index - 2

ISSN - 1768-3262

DOI - 10.4267/2042/68970

Subject(s) - lymphoblastic leukemia , cancer research , acute lymphocytic leukemia , leukemia , medicine , gene , biology , genetics

T-cell acute lymphoblastic leukemia is identified in 10-25% of all newly diagnosed acute lymphoblastic leukemia's in children. The disease results from cytogenetic and molecular abnormalities which disrupt key oncogenic, tumor suppressor, and developmental pathways which control normal thymocyte development. Disruption of key pathways alter normal control of cell growth and proliferation, along with survival and differentiation. This paper provides an update on the cytogenetic and molecular basis of pediatric T-cell acute lymphoblastic leukemia.

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