Open AccessBCL2 (B-Cell Leukemia/Lymphoma 2)
Author(s) -
Anwar N. Mohamed
Publication year - 2018
Publication title -
atlas of genetics and cytogenetics in oncology and haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.121
H-Index - 2
ISSN - 1768-3262
DOI - 10.4267/2042/68938
Subject(s) - leukemia , lymphoma , cancer research , biology , gene , genetics , computational biology , immunology
BCL2 is the milestone of apoptosis-regulatory genes. It contributes to tumorigenesis by blocking programmed cell death as such, promoting cell survival. The aberrant expression of BCL2 gene is strongly associated with resistance to chemotherapy and radiation. This review outlines the structure, function, and role of BCL2 gene in cancer.
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