FZD4 (frizzled class receptor 4) | Zendy

Alessandro Beghini | Zendy; Adriana Cassaro | Zendy

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FZD4 (frizzled class receptor 4)

Author(s) -

Alessandro Beghini,

Adriana Cassaro

Publication year - 2018

Publication title -

atlas of genetics and cytogenetics in oncology and haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.121

H-Index - 2

ISSN - 1768-3262

DOI - 10.4267/2042/68929

Subject(s) - frizzled , genetics , class (philosophy) , biology , computational biology , gene , microbiology and biotechnology , wnt signaling pathway , computer science , artificial intelligence

Fzd4 is a receptor for Wnt proteins, belonging to the frizzled receptors family. Its stimulation can activate both Wnt/β-catenin canonical and Wnt/Ca non canonical pathways. This receptor plays an important role in the development processes, in particular in the retinal vascularization: it binds the Norrin ligand, a Wnt-unrelated growth factor, and activates β-catenin signalling pathway. Mutations of FZD4 gene are associated with Familial Exudative Vitreoretinopathy (FEVR). Recently dysregulation of FZD4 expression has been reported in different type of cancers, but FZD4 contribution in tumor pathogenesis and progression is still not entirely elucidated.

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