SNW1 (SNW domain containing 1) | Zendy

Çağla Ece Olgun | Zendy; Mesut Muyan | Zendy

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SNW1 (SNW domain containing 1)

Author(s) -

Çağla Ece Olgun,

Mesut Muyan

Publication year - 2018

Publication title -

atlas of genetics and cytogenetics in oncology and haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.121

H-Index - 2

ISSN - 1768-3262

DOI - 10.4267/2042/68909

Subject(s) - genetics , biology , computational biology

SNW1 is a spliceosomal component and transcriptional co-regulator that provides a modulatory coupling of transcription initiation and splicing. SNW1 appears to be an essential cancer cell survival factor by co-transcriptionally regulating mRNA splicing of proteins involved in cell cycle checkpoints. As a co-regulator, SNW1 is shown to attune the activity of a number of transcription factors, including nuclear hormone receptors as well as CBF1, Smad2/3, and MyoD by modulating a transition step between the repressing and activating transcription complex assembly. SNW1 is also involved in the cell cycle progression through the involvement in cell cycle checkpoint-dependent changes in gene expressions during cellular proliferation and viral infections.

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