HDAC1 (histone deacetylase 1) | Zendy

Emanuely Silva Chrun | Zendy; Filipe Modolo | Zendy; Filipe Ivan Daniel | Zendy

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HDAC1 (histone deacetylase 1)

Author(s) -

Emanuely Silva Chrun,

Filipe Modolo,

Filipe Ivan Daniel

Publication year - 2018

Publication title -

atlas of genetics and cytogenetics in oncology and haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.121

H-Index - 2

ISSN - 1768-3262

DOI - 10.4267/2042/68900

Subject(s) - hdac1 , hdac11 , genetics , histone deacetylase , histone , biology , gene

HDAC1 is a Class I histone deacetylase (HDACs) encoded by this gene. HDACs remove acetyl group from amino-terminal tail of histone lysine recovering the positive charge of histone tail, permitting interactions between negatively charged DNA and histone protein, resulting in chromatin structure condensation which is associated with gene repression. Overexpression of this protein has been related to several malignancies, controlling tumour suppressor genes expression, feasible prognostics factor, and medications target. This paper propound data about HDAC1 gene, its protein encoded and function.

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